The Nobel Committee announced the award
of 2009 Nobel Chemistry Prize to Dr. Venkatraman Ramakrishnan, along with two
others – Thomas Steitz of Yale University , US , and Ada Yonath of the Weizmann Institute of
Science in Israel
– for their discovery on how the genetic code is translated into the molecules
of life.
The three, using a technique called X-ray
crystallography, mapped the position of each of the hundreds of thousands of atoms
that make up the ribosome. The three-dimensional models developed by them
revealed how the ribosome reads the genetic code of DNA and convert it into the
protein molecules that control all biochemical processes.
Their research into the ribosome’s working
will help scientists understand the life better—how the core processes
function. That aside, it has a practical utility: paving the way for improving
antibiotics’ ability to disable ribosomes in bacteria. The knowledge of the
precise structure of the ribosome will facilitate better understanding of how
the instructions of the messenger molecule trapped between the two pieces of
ribosome are used to assemble the protein that the gene encodes out of smaller
molecules called amino acids and thereby facilitate better designing of drugs –
antibiotics – that interfere with the ribosome’s function. The discoveries of these three scientists
reveal how antibiotics— the chemicals that kill disease-generating bacteria by
blocking the function of their ribosomes—bind to the ribosomes precisely, which
knowledge several drug manufacturers are today using to develop new molecules
that would bind to that site bur perhaps more specifically or with fewer side
effects.
The whole nation rejoiced the news—of an
India-born American citizen, winning the Nobel. Venkatraman was born in
Chidambaram in Tamilanadu and educated in Gujarat but emigrated to the US 25
years back. He started working on ribosomes as a postdoctoral fellow at the Yale University
in the US and is currently working
at the Laboratory of Molecular Biology in Cambridge ,
England . Suddenly,
every educated Indian started talking gloatingly about India ’s
competency in science and technology.
To be happy about a fellow Indian’s great
achievement is alright. But that is not
imperative here. What matters most now is what are we, as nation, doing to
produce such scientists and scientific discoveries. As Madhavan Nair, the ISRO
Chairman, observed, of course, in a different context: “the level of education
and knowledge being imparted by many colleges …they are not up to the mark.
Instead of concentrating on quantity, these institutions should concentrate on
quality”. Madhavan Nair also warned that if the quality of education is not
improved the nation will only have people for clerical or routine jobs.
Similar warning echoes in what the
President of Indian National Academy said: “the structure of Indian science is
unequal to the requirements of modern scientific research.” This obviously
calls for rejigging our educational system. As the academicians are demanding
for, “true interdisciplinarity” must be introduced at the under-graduate level
itself. It is pertinent to bear in mind here what the Nobel laureate himself has
said about what helped him in the pursuit of his research goals: “My earlier
exposure to physics certainly helped me in the use of biophysical techniques
like crystallography, the use of computing, calculations, etc.”
Instead of gloating about Venkatraman’s
Nobel prize or cribbing at the absence of many such Indians in the ranks of
Nobel Laureates, what the government should do is revamp the educational system to inject
‘multidisplinarity’ into education at the under graduation level itself. And
importantly, as Venkatraman desired “…what the government should do is
concentrate on building a broad culture of respect for basic science and
knowledge.”
Of being happy of Venki’s Nobel is fast
waning; the urgency for action on its imperative is not.
* * *
* * *
It’s almost five years since these
thoughts have been shared and if we look for the positive developments if any
on this score, we are just ending up with a disappointment. For, nothing
substantial has been done since 2009 except for establishing six Indian
Institutes of Science Education and Research, where “teaching and education are
totally integrated with state-of-the-art
research” meant to “nurture both curiosity and creativity in an intellectually
vibrant atmosphere” across the country.
What then is in store?
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